Publications

Peer-Reviewed Publications

  1. Kato H, Sigdel TK, Sheta M, Omori K, Qi M, Kandeel F, Komatsu H. Long-term culture of human pancreatic islets reveals reduced metal ion pathways in their gene signature. Cell Transplant. 2025;34:9636897251390960. doi: 10.1177/09636897251390960. Epub 2025 Nov 22. PMID: 41273109.
  2. Shang KM, Suzuki T, Kato H, Toyoda T, Tai YC, Komatsu H. Oxygen dynamics and delivery strategies to enhance beta cell replacement therapy. Am J Physiol Cell Physiol. 2025, 5, 2019-2026 Apr 9. doi: 10.1152/ajpcell.00984.2024. Online ahead of print. PMID: 40204281.
  3. Chen H, Zeng T, Yoshitomi T, Kawazoe N, Komatsu H, Yang Y, Chen G. Porous microwell scaffolds for 3D culture of pancreatic beta cells to promote cell aggregation and insulin secretion. Mater Adv. 2024. doi: 10.1039/D3MA01048A.
  4. Lenz G, Miao L, Lenz A, Mares J, Quijano J, Zook HN, Komatsu H, Garcia P, Ferreri K, Ku HT, Kandeel F. Characterization of Human Pancreatic Islet Cells using a Single-Cell Western Blot Platform. Pancreas. 2024 Nov-Dec 01;53(10):e818-e829. doi: 10.1097/MPA.0000000000002385. Epub 2024 Sep 12. PMID: 39259841.
  5. Kato H, Salgado M, Mendez D, Gonzalez N, Rawson J, Ligot D, Balandran B, Orr C, Quijano JC, Omori K, Qi M, Al-Abdullah IH, Mullen Y, Ku HT, Kandeel F, Komatsu H. Biological hypoxia in pre-transplant human pancreatic islets induces transplant failure in diabetic mice. Sci Rep. 2024 May 30;14(1):12402. doi: 10.1038/s41598-024-61604-3. PMID: 38811610. PMCID: PMC11137081.
  6. Kato H, Chen H, Shang KM, Izumi K, Koba N, Tsuchiya T, Kawazoe N, Quijano J, Omori K, Orr C, Qi M, Ku HT, Kandeel F, Tai YC, Chen G, Komatsu H. Physiomimetic fluidic culture platform on microwell-patterned porous collagen scaffold for human pancreatic islets. Cell Transplant. 2024 Jan-Dec;33:9636897241249556. doi: 10.1177/09636897241249556. PMID: 38742734. PMCID: PMC11095165.
  7. Shang KM, Kato H, Gonzalez N, Kandeel F, Tai YC, Komatsu H. A novel approach to determine the critical survival threshold of cellular oxygen within spheroids via integrating live/dead cell imaging with oxygen modeling. Am J Physiol Cell Physiol. 2024 Apr 1;326(4). doi: 10.1152/ajpcell.00024.2024. Epub 2024 Mar 18. PMID: 38497111.
  8. Kobayashi E, Hakamata Y, Enosawa S, Shang KM, Komatsu H. Firefly Rats: Illuminating the Scientific Community in Transplantation Research. Cell Transplant. 2024 Jan-Dec;33:9636897231224174. doi: 10.1177/09636897231224174. PMID: 38235662.
  9. Omori K, Qi M, Salgado M, Gonzalez N, Hui LT, Chen KT, Rawson J, Miao L, Komatsu H, Isenberg JS, Al-Abdullah IH, Mullen Y, Kandeel F. A scalable human islet 3D-culture platform maintains cell mass and function long-term for transplantation. Am J Transplant. 2023 Oct 7:S1600-6135(23)00790-6. doi: 10.1016/j.ajt.2023.10.001. Online ahead of print. PMID: 37813189.
  10. Gonzalez N, Kato H, Tixi W, Ortiz J, Orr C, Shih HP, Ku HT, Yee JK, Kandeel F, Mullen Y, Kobayashi E, Komatsu H. Ubiquitous Luciferase Expression in “Firefly Rats” Does Not Alter the Pancreatic Islet Morphology, Metabolism, and Function. Cell Transplant. 2023 Jan-Dec;32:9636897231182497. doi: 10.1177/09636897231182497. PMID: 37345228.
  11. Myrick R, Shang KM, Betts JF, Gonzalez N, Rawson J, Izumi K, Koba N, Tsuchiya T, Kato H, Omori K, Kandeel F, Mullen Y, Tai YC, Botvinick E, Komatsu H. Micropyramid-patterned, oxygen-permeable bottomed dish for high density culture of pancreatic islets. Biofabrication. 2022 Dec 20;15(1). doi: 10.1088/1758-5090/aca79a. PMID: 36537072.
  12. Kato H, Miwa T, Quijano J, Medrano L, Ortiz J, Desantis A, Omori K, Wada A, Tatsukoshi K, Kandeel F, Mullen Y, Ku HT, Komatsu H. Microwell culture platform maintains viability and mass of human pancreatic islets. Front Endocrinol (Lausanne). 2022 Nov 17;13:1015063. doi: 10.3389/fendo.2022.1015063. eCollection 2022. PMID: 36465665.
  13. Omori K, Gonzalez I, Nguyen C, Raminani SN, Deleon VM, Meza P, Zamalloa J, Perez RG, Gonzalez N, Komatsu H, Al-Abdullah IH, Wen X. Submilligram Level of Beetle Antifreeze Proteins Minimize Cold-Induced Cell Swelling and Promote Cell Survival. Biomolecules. 2022 Oct 28;12(11):1584. doi: 10.3390/biom12111584. PMID: 36358934.
  14. Li J, Komatsu H, Poku E, Olafsen T, Huang K, Huang L, Chea J, Bowles N, Chang B, Rawson J, Peng J, Wu A, Shively J, Kandeel F. Biodistribution of Intra-Arterial and Intravenous Delivery of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in a Rat Model to Guide Delivery Strategies for Diabetes Therapies. Pharmaceuticals (Basel). 2022 May 12;15(5):595. doi: 10.3390/ph15050595. PMID: 35631421.
  15. Komatsu H, Kobayashi E, Gonzalez N, Rawson J, Ortiz J, Donohue C, Ku HT, Kandeel F, Mullen Y. Critical Considerations in Bioluminescence Imaging of Transplanted Islets: Dynamic Signal Change in Early Posttransplant Phase and Signal Absorption by Tissues. Pancreas. 2022 Mar 1;51(3):234-242. doi: 10.1097/MPA.0000000000002004. PMID: 35584380.
  16. Komatsu H†, Qi M†, Gonzalez N, Salgado M, Medrano L, Rawson J, Orr C, Omori K, Isenberg JS, Kandeel F, Mullen Y, Al-Abdullah IH. A Multiparametric Assessment of Human Islets Predicts Transplant Outcomes in Diabetic Mice. Cell Transplant. Jan-Dec 2021;30:9636897211052291. doi: 10.1177/09636897211052291. PMID: 34628956 († co-first authors).
  17. Komatsu H, Gonzalez N, Ortiz J, Rawson J, Omori K, Kandeel F, Mullen Y. Early-Phase Luciferase Signals of Islet Grafts Predicts Successful Subcutaneous Site Transplantation in Rats. Mol Imaging Biol. 2021 Apr;23(2):173-179. doi: 10.1007/s11307-020-01560-2. Epub 2020 Nov 2. PMID: 33140260.
  18. Komatsu H, Gonzalez N, Kandeel F, Mullen Y. Intermittent normobaric oxygen inhalation enhances subcutaneous prevascularization for cell transplantation. Microvasc Res. 2020 Nov;132:104070. doi: 10.1016/j.mvr.2020.104070. PMID: 32890600.
  19. Komatsu H, Salgado M, Gonzalez N, Medrano L, Rawson J, Omori K, Qi M, Al-Abdullah I, Kandeel F, Mullen Y. High fractions of large islets in human islet preparations detrimentally affect post-transplant outcomes in streptozotocin-induced diabetic immunodeficient mice. Pancreas. 2020, May/Jun;49(5):650-654. doi: 10.1097/MPA.0000000000001541. PMID: 32433402.
  20. Salgado M, Gonzalez N, Medrano L, Rawson J, Omori K, Qi M, Al-Abdullah I, Kandeel F, Mullen Y, Komatsu H. Semi-automated assessment of human islet viability predicts transplantation outcomes in a diabetic mouse model. Cell Transplant. 2020, Jan-Dec;29:963689720919444. doi: 10.1177/0963689720919444. PMID: 32410459.
  21. Komatsu H, Gonzalez N, Salgado M, Cook CA, Li J, Rawson J, Omori K, Tai YC, Kandeel F, Mullen Y. A subcutaneous pancreatic islet transplantation platform using a clinically applicable, biodegradable Vicryl mesh scaffold – an experimental study. Transpl Int. 2020 Mar 21. doi: 10.1111/tri.13607. Online ahead of print. PMID: 32198960.
  22. Gonzalez N, Salgado M, Medrano L, Mullen Y, Komatsu H. Isolated pancreatic islet yield and quality is inversely related to organ donor age in rats. Exp Gerontol. 2019 Dec;128:110739. doi: 10.1016/j.exger.2019.110739. Epub 2019 Oct 18. PMID: 31634542.
  23. Cook C†, Komatsu H†, Salgado M, Mullen Y, Kandeel F, Tai Y-C, editors. MEMS Silicon Cutters for Rapid Sectioning of Diffusion-Limited Pancreatic Islets to Improve Viability. Actuators and Microsystems & Eurosensors. 2019. († Co-first authors).
  24. Komatsu H, Cook CA, Gonzalez N, Medrano L, Salgado M, Sui F, Li J, Kandeel F, Mullen Y, Tai YC. Oxygen transporter for the hypoxic transplantation site. Biofabrication. 2018 Dec 7;11(1):015011. PMID: 30524058.
  25. Komatsu H, Salgado M, Medrano L, Omori K, Kandeel K, Mullen Y. Surfactants Improve Live Cell Imaging of Human Pancreatic Islets. Pancreas. 2018 Oct;47(9):1093-1100. PMID: 30142118.
  26. Komatsu H, Rawson J, Medrano L, Cook AC, Barriga A, Gonzalez N, Salgado M, Omori K, Kandeel F, Tai Y, Mullen Y. Optimizing temperature and oxygen supports long-term culture of human islets. Transplantation. 2019 Feb;103(2):299-306. PMID: 29781952.
  27. Komatsu H, Kandeel K, Mullen Y. Impact of oxygen on pancreatic islet survival, Review, Pancreas. 2018 May/Jun;47(5):533-543. PMID: 29621044.
  28. Komatsu H, Rawson J, Barriga A, Gonzalez N, Mendez D, Li J, Omori K, Kandeel F, Mullen Y. Posttransplant oxygen inhalation improves the outcome of subcutaneous islet transplantation: A promising clinical alternative to the conventional intrahepatic site. Am J Transplant. 2017 Sep 12. PMID: 28898528.
  29. Komatsu H, Cook C, Wang CH, Medrano L, Lin H, Kandeel F, Tai YC, Mullen Y. Oxygen environment and islet size are the primary limiting factors of isolated pancreatic islet survival. PLoS One. 2017 Aug 23;12(8):e0183780. doi: 10.1371/journal.pone.0183780. eCollection 2017. PMID: 28832685.
  30. Komatsu H, Barriga A, Medrano L, Omori K, Kandeel F, Mullen Y. Oxygenated thawing and rewarming alleviate rewarming injury of cryopreserved pancreatic islets. Biochem Biophys Res Commun. 2017 May 6;486(3):817-823. PMID: 28351620.
  31. Komatsu H, Kang D, Lin H, Cook AC, Mendez D, Rawson J, Mullen Y, Kandeel F, Tai Y. MEMS oxygen transport device for islet transplantation in the subcutaneous site. Micro & Nano Letters. 2016 Oct. 11(10):632-5.
  32. Komatsu H, Kang D, Medrano L, Barriga A, Mendez D, Rawson J, Omori K, Ferreri K, Tai Y, Kandeel F, Mullen Y. Isolated human islets require hyperoxia to maintain islet mass, metabolism, and function. Biochem Biophys Res Commun. 2016 Feb 12;470(3):534-8. PMID: 26801563.
  33. Omori K, Kobayashi E, Komatsu H, Rawson J, Agrawal G, Parimi M, Oancea AR, Valiente L, Ferreri K, Al-Abdullah IH, Kandeel F, Takahashi M, Mullen Y. Involvement of a pro-apoptotic gene BBC3 in islet injury mediated by cold preservation and re-warming. Am J Physiol Endocrinol Metab. 2016 Apr 26 PMID: 27117005.
  34. Komatsu H, Omori K, Parimi M, Rawson J, Kandeel F, Mullen Y. Determination of islet viability using a zinc-specific fluorescent dye and a semi-automated assessment method. Cell Transplant. 2015 Oct 22. PMID: 26497578.
  35. Taki K, Ohmuraya M, Tanji E, Komatsu H, Hashimoto D, Semba K, Araki K, Kawaguchi Y, Baba H, Furukawa T. GNASR201H and KrasG12D cooperate to promote murine pancreatic tumorigenesis recapitulating human intraductal papillary mucinous neoplasm. Oncogene. 2015 Aug 10. PMID: 26257060.
  36. Omori K, Komatsu H, Rawson J, Mullen Y. Pharmacological Strategies for Protection of Extrahepatic Islet Transplantation. Minerva Endocrinol. 2015 Jun;40(2):85-103. PMID: 25651758.
  37. Komatsu H, Egawa S, Motoi F, Morikawa T, Sakata N, Naitoh T, Katayose Y, Ishida K, Unno M. Clinicopathological features and surgical outcomes of adenosquamous carcinoma of the pancreas: a retrospective analysis of patients with resectable stage tumors. Surg Today. 2015 Mar;45(3):297-304. PMID: 24973941.
  38. Komatsu H, Tanji E, Sakata N, Aoki T, Motoi F, Naitoh T, Katayose Y, Egawa S, Unno M, Furukawa T. A GNAS mutation found in pancreatic intraductal papillary mucinous neoplasms induces drastic alterations of gene expression profiles with upregulation of mucin genes. PLoS One. 2014 Feb 3;9(2):e87875. PMID: 2449838.
  39. Komatsu H, Sakata N, Motoi F, Naitoh T, Katayose Y, Rikiyama T, Egawa S, Kasajima A, Ishida K, Unno M. A case of intrahepatic cholangiocellular carcinoma occurring three years after resection for advanced pancreatic cancer. (in Japanese) SUIZO. 26(5): 589-597, 2011.
  40. Komatsu H, Yoshida H, Hayashi H, Sakata N, Morikawa T, Onogawa T, Motoi F, Rikiyama T, Katayose Y, Egawa S, Hirota M, Shimosegawa T, Unno M. Fulminant type of Emphysematous pancreatitis has risk of massive hemorrhage. Clin J Gastroenterol. 2011 Aug;4(4):249-54. PMID: 26189529.
  41. Komatsu H, Tsuchiya T, Honda H, Naito T, Oikawa M, Kakita T, Oyama A, Yazawa T, Miura Y, Sawai T. Aggressive surgery aids long-term IVC leiomyosarcoma survival: report of a case. (in Japanese) The Japanese journal of gastroenterological surgery. 44(4): 510-518, 2011.
  42. Komatsu H, Yoshida H, Onogawa T, Katayose Y, Rikiyama T, Egawa S, Unno M. A case of Methicillin-resistant Staphylococcus Aureus endocarditis treated with valve replacement and long-term antibiotic therapy following distal pancreatectomy. (in Japanese) J. Jpn. Soc. Surg. Infect 7(3): 285-291, 2010.
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